Premier League leaders Manchester City can ensure Manchester United's recent revival is short-lived by opening up a 12-point gap on their local rivals on Sunday.
Meanwhile, a series of tributes are planned as Leicester return to the King Power Stadium for the first time since club owner Vichai Srivaddhanaprabha and four other people were tragically killed in a helicopter crash.
Reigning champions Manchester City hold just a two-point lead over Chelsea and Liverpool at the top, but have looked relentless in recent weeks and shown no sign of a slip in standards from their record-breaking 100-point Premier League campaign of last season, scoring 12 times in their last two outings.
One of precious few blemishes from last term, though, was blowing the chance to claim the title by beating United at the Etihad as City threw away a 2-0 half-time lead to lose 3-2.
That result only marginally stemmed the tide in the power shift across Manchester towards City since Sir Alex Ferguson's retirement in 2013. United have failed to finish above City in the league since, and are already nine points behind the leaders.
However, Jose Mourinho's men were also buoyed by their best result of the season on Wednesday, winning at Juventus in dramatic fashion.
Defensive concerns remain for Mourinho, though, with United keeping just one clean sheet in their last 10 matches.
Meanwhile, two weeks after Vichai's helicopter crashed in the car park of the King Power the Foxes will again pay tribute to the man who helped produce one of the greatest upsets in sporting history as a team labelled a 5,000-1 shot won the Premier League in 2016.
Tributes will be made ahead of kick-off with an expected 20,000 fans set to take part in a walk from Leicester city centre to the stadium in Vichai's honour, as well as a video tribute before kick-off and a two-minute silence.
Saturday: Cardiff v Brighton, Huddersfield v West Ham, Leicester v Burnley, Newcastle v Bournemouth, Southampton v Watford, Crystal Palace v Tottenham
Sunday: Liverpool v Fulham, Chelsea v Everton, Arsenal v Wolves, Manchester City v Manchester United